刺激响应性聚（2-二甲氨基乙基甲基丙烯酸酯）-嵌段-富勒烯（PDMAEMA-b-C60）的合成与自组装以及游离 PDMAEMA 链引起的去胶束化。

Synthesis and self-assembly of stimuli-responsive poly(2-(dimethylamino) ethyl methacrylate)-block-fullerene (PDMAEMA-b-C60) and the demicellization induced by free PDMAEMA chains.

机构信息

Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1.

出版信息

Langmuir. 2011 Jun 7;27(11):6668-73. doi: 10.1021/la200885h. Epub 2011 May 16.

DOI:10.1021/la200885h

PMID:21568352

Abstract

Well-defined poly(2-(dimethylamino) ethyl methacrylate)-block-fullerene [60] ((PDMAEMA)-b-C(60)) with a galactose targeting moiety was prepared by atom-transfer radical polymerization (ATRP). This copolymer was designed for possible use as a targeted drug carrier. The chemical composition and the self-assembly behavior were characterized using different techniques, including GPC, NMR, UV, and DLS. The self-assembly of the galactose-functionalized PDMAEMA-b-C(60) structure in aqueous solutions was investigated using dynamic light scattering (DLS) under different pH conditions. At pH 3 and 10, the DLS results showed the presence of both polymeric micelles and unimers. However, a smaller R(h) was observed at pH 10 than at pH 3 because of electrostatic repulsion at low pH values. In addition, free PDMAEMA chains induced the demicellization of self-assembled nanostructures caused by the formation of a charge-transfer complex between PDMAEMA and C(60.) This phenomenon offers possible applications for free-polymer-triggered drug release.

摘要

通过原子转移自由基聚合（ATRP）制备了具有半乳糖靶向部分的明确界定的聚（2-（二甲氨基）乙基甲基丙烯酸酯）-嵌段-富勒烯 [60]（（PDMAEMA）-b-C（60））。该共聚物被设计用于可能用作靶向药物载体。使用不同的技术，包括 GPC、NMR、UV 和 DLS，对共聚物的化学组成和自组装行为进行了表征。在不同 pH 值条件下，使用动态光散射（DLS）研究了半乳糖功能化 PDMAEMA-b-C（60）结构在水溶液中的自组装。在 pH 3 和 10 下，DLS 结果表明存在聚合物胶束和单体。然而，由于在低 pH 值下存在静电排斥，在 pH 10 下观察到的 R(h) 比在 pH 3 下小。此外，由于 PDMAEMA 和 C（60）之间形成电荷转移复合物，游离的 PDMAEMA 链诱导自组装纳米结构的去胶束化。这种现象为游离聚合物触发的药物释放提供了可能的应用。