Department of Pediatrics, Mackay Memorial Hospital, Taiwan.
Pediatr Crit Care Med. 2011 Nov;12(6):e424-7. doi: 10.1097/PCC.0b013e3182192c8d.
To report the successful use of rasburicase in two children with hyperuricemia secondary to severe rhabdomyolysis.
: Case report.
Pediatric intensive care unit in a freestanding quaternary hospital.
Two pediatric patients with severe rhabdomyolysis and hyperuricemia caused by ecstasy intoxication and exertional heat stroke.
Use of a single low dose (6 mg) of rasburicase, a urate oxidase enzyme.
Rasburicase was administered on the first and second hospital days with a single low dose of 6 mg (0.086 mg/kg in patient A and 0.092 mg/kg in patient B). Within 24 hrs, the levels of serum uric acid in both patients decreased dramatically, and their creatinine levels decreased and urine output increased concurrently. Continuous improvements in the uric acid levels, creatinine levels, and urine output were noted during hospitalization.
Rasburicase seems to be a safe and effective drug for improving hyperuricemia in patients with rhabdomyolysis and renal failure.
报告两例因严重横纹肌溶解导致高尿酸血症的患儿成功应用别嘌醇酶的病例。
病例报告。
一家独立的四级医院的儿科重症监护病房。
两名因摇头丸中毒和剧烈运动性中暑导致严重横纹肌溶解和高尿酸血症的儿科患者。
使用单次低剂量（6 毫克）别嘌醇酶，一种尿酸氧化酶。
在入院第 1 天和第 2 天给予单次低剂量 6 毫克（患者 A 为 0.086 mg/kg，患者 B 为 0.092 mg/kg）。在 24 小时内，两名患者的血清尿酸水平均显著下降，肌酐水平下降，尿量增加。在住院期间，尿酸水平、肌酐水平和尿量持续改善。
别嘌醇酶似乎是一种安全有效的药物，可改善横纹肌溶解和肾衰竭患者的高尿酸血症。
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