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肿瘤在细胞群落中的自主性与失范起源(假说)

Origin of autonomy and anomie of tumors in cell society (hypothesis).

作者信息

Chigira M

出版信息

Int J Oncol. 1993 Apr;2(4):583-6. doi: 10.3892/ijo.2.4.583.

Abstract

In multicellular organisms, internal evolution of individual cells is strictly forbidden and 'evolutional' DNA replication should be performed only by the sexual reproduction system in these organisms, although in malignant tumors, it seems that individual cells replicate 'selfishly' and evolve against the internal micro-environment. This phenomenon is based on the failure of identical DNA replication, and results in 'anomie' of cellular society. Genetic programs of normal cells connote this cellular anomie, since they are introduced by the deletion of regulators on structure genes and cells have clearly been evolved from 'monads' in which cells proliferate without regulation. Tumor heterogeneity and progression can be fully explained by this self-contradictory process which produces heterogeneous gene copies different from the original clone in the tumor, although 'selfish' gene replication is the final target of being.

摘要

在多细胞生物中,单个细胞的内部进化是严格禁止的,“进化性”DNA复制应该仅由这些生物中的有性生殖系统来进行,尽管在恶性肿瘤中,单个细胞似乎会“自私地”复制并针对内部微环境进行进化。这种现象基于相同DNA复制的失败,并导致细胞社会的“失范”。正常细胞的遗传程序暗示了这种细胞失范,因为它们是由结构基因上调节因子的缺失引入的,并且细胞显然是从无调节增殖的“单体”进化而来的。肿瘤异质性和进展可以通过这个自相矛盾的过程得到充分解释,这个过程在肿瘤中产生与原始克隆不同的异质基因拷贝,尽管“自私”的基因复制是存在的最终目标。

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