鉴定猪 Pitx2c 基因中的四个 SNPs 与肉质性状的关联分析。
Identification of four SNPs and association analysis with meat quality traits in the porcine Pitx2c gene.
机构信息
Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, College of Animal Science, Huazhong Agricultural University, Wuhan, 430070, China.
出版信息
Sci China Life Sci. 2011 May;54(5):426-33. doi: 10.1007/s11427-011-4167-9. Epub 2011 May 15.
The association of the porcine Pitx2c gene with meat quality traits was investigated in the present study. A total of eight single nucleotide polymorphisms (SNPs) were found. Allele frequencies of four SNPs were further detected in four commercial breeds and eight Chinese indigenous breeds. Single SNP and meat quality associations were analyzed in a Yorkshire×Meishan F(2) population. The SNPs c.474C>T (P<0.01) and c.636C>T (P<0.05) showed a significant association with meat color (MCV1). The SNPs c.*37G>A and c.*47G>A were significantly associated with drip loss rate (DLR), water holding capacity (WHC) and meat color value (MCV1) consistently (P<0.05). Linkage disequilibrium (LD) analysis revealed that the adjacent SNPs were in LD. Two major haplotypes were identified, and association analysis between haplotype combinations and meat quality indicated that the presence of two copies of haplotype 1 -CCGG- may improve meat quality.
本研究旨在探讨猪 Pitx2c 基因与肉质性状的关系。共发现了 8 个单核苷酸多态性（SNP）。在四个商业品种和八个中国本土品种中进一步检测到四个 SNP 的等位基因频率。在 Yorkshire×Meishan F(2)群体中分析了单 SNP 与肉质的关联。SNP c.474C>T（P<0.01）和 c.636C>T（P<0.05）与肉色（MCV1）显著相关。SNP c.*37G>A 和 c.*47G>A 与滴水损失率（DLR）、水分保持能力（WHC）和肉色值（MCV1）显著相关（P<0.05）。连锁不平衡（LD）分析表明，相邻 SNP 处于 LD 状态。鉴定出两种主要单倍型，单倍型组合与肉质的关联分析表明，存在两份单倍型 1 -CCGG-可能会改善肉质。
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