Razek Ahmed Abdel Khalek Abdel, Farouk Ahmed, Mousa Amani, Nabil Nancy
Diagnostic Radiology Department, Mansoura Faculty of Medicine, Mansoura University Hospital, Mansoura, Egypt.
J Comput Assist Tomogr. 2011 May-Jun;35(3):332-6. doi: 10.1097/RCT.0b013e318219fe76.
To evaluate the role of diffusion-weighted magnetic resonance (MR) imaging in the characterization of renal tumors.
Prospective study was conducted on 52 consecutive patients (24 males and 28 females) with renal tumor. They underwent diffusion-weighted echo planar MR imaging of the abdomen with b-factor of 0 and 800 seconds/mm². The apparent diffusion coefficient (ADC) value of the renal tumor was calculated and correlated with histopathological results.
The mean ADC value of malignant renal tumors (1.56 ± 0.26 × 10⁻³ mm²/s) was significantly different (P = 0.001) from that of benign tumors (1.87 ± 0.50 × 10⁻³ mm²/s). Selection of 1.84 × 10⁻³ mm²/s as a cutoff point of ADC value to predict renal malignancy revealed accuracy of 89%, sensitivity of 89%, and specificity of 89%. The cutoff point of ADC value to differentiate renal cell carcinoma (RCC) from other malignancy (1.15 × 10⁻³ mm²/s) revealed 72% accuracy, 95% sensitivity, 50% specificity. The cutoff point of ADC value used to differentiate clear and papillary RCC from other subtypes of RCC was 1.84 × 10⁻³ mm²/s with an accuracy of 89%, sensitivity of 89%, and specificity of 89%.
Apparent diffusion coefficient value can differentiate benign from malignant renal tumors and may be helpful for the differentiation of the histologic subtypes of RCC.
评估扩散加权磁共振成像在肾肿瘤特征描述中的作用。
对52例连续的肾肿瘤患者（24例男性和28例女性）进行前瞻性研究。他们接受了腹部扩散加权回波平面磁共振成像，b值分别为0和800秒/平方毫米。计算肾肿瘤的表观扩散系数（ADC）值，并将其与组织病理学结果相关联。
恶性肾肿瘤的平均ADC值（1.56±0.26×10⁻³平方毫米/秒）与良性肿瘤（1.87±0.50×10⁻³平方毫米/秒）相比有显著差异（P = 0.001）。选择1.84×10⁻³平方毫米/秒作为预测肾恶性肿瘤的ADC值截止点，显示准确率为89%，敏感性为89%，特异性为89%。用于区分肾细胞癌（RCC）与其他恶性肿瘤的ADC值截止点（1.15×10⁻³平方毫米/秒）显示准确率为72%，敏感性为95%，特异性为50%。用于区分透明细胞和乳头状RCC与其他RCC亚型的ADC值截止点为1.84×10⁻³平方毫米/秒，准确率为89%，敏感性为89%，特异性为89%。
表观扩散系数值可区分良性和恶性肾肿瘤，可能有助于肾细胞癌组织学亚型的鉴别。
