Matucci-Cerinic M, Pignone A, Lotti T, Spillantini G, Curradi C, Leoncini G, Iannone F, Falcini F, Cagnoni M
Institute of Clinical Medicine IV, University of Florence, Italy.
J Rheumatol. 1990 Mar;17(3):328-30.
Decreased levels of angiotensin converting enzyme plasma activity were found in systemic sclerosis. No relationship with clinical characteristics of the disease and increased von Willebrand factor antigen concentration (a widely accepted marker of endothelial injury) were statistically demonstrated. An inverse relationship between the reduced activity of the enzyme and erythrocyte sedimentation rate was detected (r = 0.410, p less than 0.05). We hypothesize that in systemic sclerosis, angiotensin converting enzyme activity might be affected by a decrease in endothelial production or by interference of circulating factors. Further studies are needed to determine if angiotensin converting enzyme activity could be used as a marker of endothelial injury in scleroderma.
在系统性硬化症中发现血浆血管紧张素转换酶活性水平降低。未统计学证实其与该疾病的临床特征及血管性血友病因子抗原浓度升高（内皮损伤的一个广泛认可的标志物）之间存在关联。检测到该酶活性降低与红细胞沉降率之间呈负相关（r = 0.410，p < 0.05）。我们推测，在系统性硬化症中，血管紧张素转换酶活性可能受内皮生成减少或循环因子干扰的影响。需要进一步研究以确定血管紧张素转换酶活性是否可作为硬皮病中内皮损伤的标志物。
