Mansoura Ophthalmic Center, Mansoura University, Mansoura, Egypt.
Curr Eye Res. 2011 Jun;36(6):534-9. doi: 10.3109/02713683.2011.569868.
To assess preoperative factors associated with postoperative posterior vitreous detachment (PVD) following intravitreal autologous plasmin injection in diabetic macular edema associated with vitreomacular traction.
Twenty-five eyes with diabetic macular edema associated with vitreomacular traction as documented with optical coherence tomography were included. Approximately 0.2 IU/0.2 ml of autologous plasmin was injected intravitreally. Condition of the posterior vitreous face (degree of detachment, thickness, reflectivity, and diameter of attached vitreous base) was evaluated preoperatively and postoperatively up to 3 months.
PVD was achieved in ten eyes (41.7%). There was a significant difference (P = 0.03) in mean posterior vitreous face thickness between the eyes with PVD and the eyes with failed PVD. There was a significant correlation between PVD and both posterior vitreous face thickness (P < 0.03%) and degree of posterior vitreous face reflectivity (P = 0.002).
In diabetic eyes with vitreomacular traction, the prediction of PVD after plasmin injection is governed by the condition of posterior vitreous face; mainly posterior vitreous face thickness and reflectivity. Eyes with thinner, less reflective posterior vitreous face are more likely to develop PVD.
评估玻璃体切割术治疗糖尿病性黄斑水肿伴玻璃体视网膜牵引相关的术后后玻璃体脱离（PVD）的术前相关因素。
共纳入 25 只伴有玻璃体视网膜牵引的糖尿病性黄斑水肿眼，这些眼通过光学相干断层扫描证实存在病变。将约 0.2IU/0.2ml 的自体纤溶酶注入玻璃体内。评估术前和术后 3 个月内的后玻璃体表面状况（脱离程度、厚度、反射率和附着玻璃体基底的直径）。
10 只眼（41.7%）发生 PVD。有 PVD 的眼与未发生 PVD 的眼之间的后玻璃体表面厚度平均值存在显著差异（P=0.03）。PVD 与后玻璃体表面厚度（P<0.03%）和后玻璃体表面反射率（P=0.002）均有显著相关性。
在伴有玻璃体视网膜牵引的糖尿病眼中，纤溶酶注射后 PVD 的预测取决于后玻璃体表面的状况；主要是后玻璃体表面的厚度和反射率。后玻璃体表面较薄、反射率较低的眼更容易发生 PVD。
