Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Expert Rev Clin Immunol. 2011 May;7(3):301-16. doi: 10.1586/eci.10.104.
Immunoglobulin (Ig) therapy is an important method of treatment for a number of immunological, hematological, neurological and dermatological disorders. Over the years, the range of indications in which Ig therapy, either replacement or immunomodulatory, is effective has substantially increased. Although Ig therapy was originally limited to intramuscular injection, intravenous infusion has became the most frequent route of administration, followed by subcutaneous injection. This article presents current information on indications, mechanisms of action, efficacy and practical aspects of intravenous and subcutaneous Ig replacement/immunomodulatory therapy as well as associated adverse reactions.
免疫球蛋白(Ig)治疗是治疗多种免疫、血液、神经和皮肤疾病的重要方法。多年来,Ig 治疗(替代或免疫调节)有效的适应证范围大大增加。尽管 Ig 治疗最初仅限于肌肉注射,但静脉输注已成为最常见的给药途径,其次是皮下注射。本文介绍了静脉和皮下 Ig 替代/免疫调节治疗的适应证、作用机制、疗效和实际问题以及相关不良反应的最新信息。