Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Wilrijk, Belgium.
Neurochem Res. 2011 Oct;36(10):1858-62. doi: 10.1007/s11064-011-0504-4. Epub 2011 May 20.
In order to test whether serum glutamine synthetase (GS) is of potential diagnostic value for Alzheimer's disease (AD), we set up a study to compare serum GS concentrations between AD patients and control subjects. The study population (n = 165) consisted of AD patients (n = 94) and age-matched (n = 41) and age-unmatched (n = 30) control subjects. Serum GS analysis was performed by means of ELISA. No significant differences in serum GS levels were found between the AD group and age-matched controls. Age correlated positively with serum GS concentrations in AD patients and control subjects. This study suggests that serum GS levels have no diagnostic value for AD.
为了测试血清谷氨酰胺合成酶（GS）是否对阿尔茨海默病（AD）具有潜在的诊断价值，我们开展了一项研究，比较了 AD 患者和对照组之间的血清 GS 浓度。研究人群（n = 165）包括 AD 患者（n = 94）和年龄匹配（n = 41）和年龄不匹配（n = 30）的对照组。采用 ELISA 法检测血清 GS 分析。AD 组与年龄匹配对照组之间的血清 GS 水平无显著差异。AD 患者和对照组的血清 GS 浓度与年龄呈正相关。本研究表明，血清 GS 水平对 AD 无诊断价值。
