可乐定可抑制纳洛酮诱导的人体促肾上腺皮质激素释放。
Naloxone-induced ACTH release in man is inhibited by clonidine.
作者信息
Jackson R V, Grice J E, Jackson A J, Hockings G I
机构信息
Neuroendocrine Research Unit, University Department of Medicine, Brisbane, Queensland, Australia.
出版信息
Clin Exp Pharmacol Physiol. 1990 Mar;17(3):179-84. doi: 10.1111/j.1440-1681.1990.tb01302.x.
Abstract
- Adrenergic mechanisms play an important role in regulation of ACTH release. We used the alpha 2-adrenergic agonist, clonidine, as a central nervous system inhibitor of ACTH release to see if it would alter naloxone-induced ACTH secretion in normal human volunteers. 2. There was a significant blunting of the mean peak level of ACTH and the mean peak change of ACTH from basal as well as the area under the ACTH-time curve when clonidine was given prior to naloxone. 3. We conclude that clonidine, by blocking central noradrenergic pathways, which stimulate corticotropin-releasing hormone secretion, inhibits naloxone-induced ACTH secretion. This suggests that naloxone causes ACTH release through these same central noradrenergic pathways.
摘要
- 肾上腺素能机制在促肾上腺皮质激素（ACTH）释放的调节中起重要作用。我们使用α2-肾上腺素能激动剂可乐定作为ACTH释放的中枢神经系统抑制剂，以观察其是否会改变正常人类志愿者中纳洛酮诱导的ACTH分泌。2. 在纳洛酮之前给予可乐定，ACTH的平均峰值水平、ACTH相对于基础值的平均峰值变化以及ACTH-时间曲线下面积均有显著降低。3. 我们得出结论，可乐定通过阻断刺激促肾上腺皮质激素释放激素分泌的中枢去甲肾上腺素能通路，抑制纳洛酮诱导的ACTH分泌。这表明纳洛酮通过这些相同的中枢去甲肾上腺素能通路导致ACTH释放。
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