Honsová E, Lodererová A
Pracovist& klinické a transplantacní patologie, Transplantcentrum IKEM, Praha.
Cesk Patol. 2011 Apr;47(2):40-3.
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world with an increasing incidence. Recently, an East-West consensus on the histopathologic criteria for the diagnosis of high-grade dysplastic nodules and early hepatocellular carcinoma was published. In addition to classical morphological criteria such as nucleocytoplasmic ratio, thickness of cell plates, mitotic index, and architectural disturbance, a new one--the stromal invasion--was recognized as a crucial criterion for the diagnosis of early HCC. Immunohistochemical detection of glypican--3 was shown as a specific marker for HCC that can be used to distinguish between the benign hepatocellular lesions and HCC.
肝细胞癌（HCC）是全球最常见的癌症之一，其发病率呈上升趋势。最近，关于高级别发育异常结节和早期肝细胞癌诊断的组织病理学标准达成了东西方共识。除了经典的形态学标准，如核质比、细胞板厚度、有丝分裂指数和结构紊乱外，一个新的标准——间质浸润——被认为是早期肝癌诊断的关键标准。免疫组化检测磷脂酰肌醇蛋白聚糖-3被证明是肝癌的特异性标志物，可用于区分良性肝细胞病变和肝癌。
