用gilvocarcin V加近紫外线辐射处理人二倍体成纤维细胞后对疱疹病毒空斑形成能力的抑制作用。

Inhibition of herpes virus plaquing capacity in human diploid fibroblasts treated with gilvocarcin V plus near UV radiation.

作者信息

Bockstahler L E, Elespuru R K, Hitchins V M, Carney P G, Olvey K M, Lytle C D

机构信息

Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20857.

出版信息

Photochem Photobiol. 1990 Apr;51(4):477-9. doi: 10.1111/j.1751-1097.1990.tb01740.x.

DOI:10.1111/j.1751-1097.1990.tb01740.x

PMID:2160661

Abstract

The capacity of human fibroblasts to support plaque formation by Herpes simplex virus following treatment of the cells with gilvocarcin V, a polyaromatic C-glycoside, plus near ultraviolet radiation (UVA, 320-400 nm) was examined. Gilvocarcin V, plus UVA radiation, effectively inhibited host cell capacity at concentrations five orders of magnitude lower than that of 8-methyoxypsoralen required for capacity inhibition at similar levels of UVA radiation. This result extends the observation of unusual biological potency of UVA-activated gilvocarcins from bacterial cells to human cells.

摘要

研究了用多环C-糖苷吉尔vocarcin V处理人成纤维细胞并结合近紫外辐射（UVA，320 - 400nm）后，人成纤维细胞支持单纯疱疹病毒形成斑块的能力。在与UVA辐射水平相似的情况下，吉尔vocarcin V加UVA辐射在比抑制能力所需的8-甲氧基补骨脂素浓度低五个数量级的浓度下，有效抑制宿主细胞能力。这一结果将UVA激活的吉尔vocarcin对细菌细胞的异常生物活性的观察扩展到了人类细胞。