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[神经丛神经病:肿瘤浸润还是放射损伤]

[Plexus neuropathy: tumor infiltration or radiation damage].

作者信息

Ebner I, Anderl H, Mikuz G, Frommhold H

机构信息

Universitätsklinik für Strahlentherapie, Innsbruck.

出版信息

Rofo. 1990 Jun;152(6):662-6. doi: 10.1055/s-2008-1046944.

Abstract

Plexus neuropathies often occur in patients with breast cancer after varying periods following surgery and postoperative radiotherapy. In most cases this has been ascribed to radiation fibrosis. The attempt to arrive at a clinical diagnosis fails because of the similarity of symptoms in both cases namely pain and the absence of motoric and sensory reflexes. But a clear diagnosis is of fundamental importance for further treatment. Only a surgical intervention can verify the diagnosis. In this study, the results of operative findings are presented and compared with a second group of patients who had died of breast cancer having undergone surgery and radiotherapy. The findings brought a surprising fact to light: a considerably high percentage of all patients suffered from large scale tumour infiltration in the plexus. The morphology and histopathology of these lesions are described. Possible explanations are given for the difference in lesion patterns, so that a clinical diagnosis might be derived therefrom.

摘要

神经丛神经病变常发生于乳腺癌患者术后及术后放疗后的不同时期。在大多数情况下,这被归因于放射性纤维化。由于两种情况(即疼痛以及运动和感觉反射缺失)的症状相似,所以难以做出临床诊断。但明确诊断对于后续治疗至关重要。只有手术干预才能证实诊断。在本研究中,展示了手术所见的结果,并与另一组接受过手术和放疗后死于乳腺癌的患者进行了比较。这些发现揭示了一个惊人的事实:所有患者中有相当高的比例存在神经丛的大规模肿瘤浸润。描述了这些病变的形态学和组织病理学特征。针对病变模式的差异给出了可能的解释,以便从中得出临床诊断。

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