通过体外免疫制备抗牛白血病病毒糖蛋白gp51的单克隆抗体。
Production of monoclonal antibody to bovine leukemia virus glycoprotein gp51 by in vitro immunization.
作者信息
Sasaki O, Tanaka M, Okabe T, Imanishi J
机构信息
Department of Microbiology, Kyoto Prefectural University of Medicine.
出版信息
Microbiol Immunol. 1990;34(4):401-5. doi: 10.1111/j.1348-0421.1990.tb01022.x.
The monoclonal antibody against glycoprotein gp51 of bovine leukemia virus (BLV) envelope antigen was produced by in vitro immunization. This monoclonal antibody reacted with viral antigen was observed at the 69 kilodalton (kDa) glycoprotein. However, this monoclonal antibody was not involved in neutralizing. It was shown that in comparison with in vivo immunization, in vitro immunization has some advantages, namely a short immunization period and a small antigen quantity.
通过体外免疫制备了针对牛白血病病毒（BLV）包膜抗原糖蛋白gp51的单克隆抗体。观察到该与病毒抗原发生反应的单克隆抗体作用于69千道尔顿（kDa）的糖蛋白。然而，该单克隆抗体不具有中和作用。结果表明，与体内免疫相比，体外免疫具有一些优点，即免疫期短和抗原用量少。
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