Koskela R S, Klockars M, Järvinen E, Rossi A, Kolari P J
Institute of Occupational Health, Helsinki, Finland.
IARC Sci Publ. 1990(97):43-53.
A retrospective cohort study was undertaken to investigate the cancer mortality of granite workers. The study comprised 1026 workers who took up such work between 1940 and 1971. The number of person-years was 23,434, and the number of deaths was 296. During the total follow-up period, 59 tumours were observed as compared with 54.4 expected. An excess mortality from tumours was observed in workers followed up for 20 years or more. Of the 59 tumours, 31 were lung cancers (expected 19.9), and 18 gastrointestinal cancers (expected 11.6), nine of which were stomach cancers (expected 7.1). Mortality from lung cancer was excessive for workers followed up for at least 15 years (28 observed, 12.7 expected). The results indicate that granite exposure per se may be an etiological factor in the initiation or promotion of malignant neoplasms.
开展了一项回顾性队列研究,以调查花岗岩工人的癌症死亡率。该研究包括1940年至1971年间从事此类工作的1026名工人。人年数为23434,死亡人数为296人。在整个随访期间,观察到59例肿瘤,而预期为54.4例。在随访20年或更长时间的工人中观察到肿瘤死亡率过高。在这59例肿瘤中,31例为肺癌(预期19.9例),18例为胃肠道癌(预期11.6例),其中9例为胃癌(预期7.1例)。在随访至少15年的工人中,肺癌死亡率过高(观察到28例,预期12.7例)。结果表明,接触花岗岩本身可能是恶性肿瘤发生或发展的一个病因。