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使用枸橼酸镓67的单光子发射计算机断层扫描-计算机断层扫描(SPECT-CT)在脊椎椎间盘炎管理中的应用

SPECT-CT with 67Ga-citrate in the management of spondylodiscitis.

作者信息

Domínguez M L, Lorente R, Rayo J I, Serrano J, Sánchez R, Infante J R, García L, Durán C

机构信息

Servicio de Medicina Nuclear, Hospital Universitario Infanta Cristina, Badajoz, España.

出版信息

Rev Esp Med Nucl Imagen Mol. 2012 Jan-Feb;31(1):34-9. doi: 10.1016/j.remn.2011.04.006. Epub 2011 Jun 11.

Abstract

Spondylodiscitis affects a small proportion of all patients with locomotor system infections, however its early diagnosis is important due to its potential morbidity. Magnetic resonance imaging is the diagnostic method of choice. Nonetheless, it has certain limitations and is not suitable for all patients. The conventional scintigraphic studies for evaluating spondylodiscitis are those performed with (99m)Tc-HDP and (67)Ga-citrate. However, their poor image resolution is a disadvantage of these techniques. The use of hybrid Single Photon Emission Computed Tomography-Computed Tomography (SPECT-CT) improves detection of the disease by combining functional and anatomical images. We present 9 patients with suspicion of spondylodiscitis who underwent sequential bone scintigraphy with (99m)Tc-HDP and SPECT-CT with (67)Ga-citrate, with positive findings confirmed by clinical monitoring for at least 6 months.

摘要

脊柱椎间盘炎在所有运动系统感染患者中所占比例较小,然而由于其潜在的发病率,早期诊断至关重要。磁共振成像(MRI)是首选的诊断方法。尽管如此,它有一定的局限性,并不适用于所有患者。用于评估脊柱椎间盘炎的传统闪烁扫描研究是使用(99m)锝-亚甲基二膦酸盐(Tc-HDP)和(67)镓-柠檬酸盐进行的。然而,这些技术图像分辨率较差是其缺点。混合单光子发射计算机断层扫描-计算机断层扫描(SPECT-CT)的应用通过结合功能图像和解剖图像提高了疾病的检测率。我们报告了9例疑似脊柱椎间盘炎的患者,他们先接受了(99m)Tc-HDP骨闪烁扫描,然后接受了(67)Ga-柠檬酸盐SPECT-CT检查,并通过至少6个月临床监测证实检查结果为阳性

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