一只年轻的斯普拉格-道利大鼠肝脏中的自发性两亲性病灶。
Spontaneous amphophilic focus in the liver of a young Sprague-Dawley rat.
作者信息
Sato Hiroko, Sakairi Tetsuya, Takagi Shiro, Kitamura Kazuyuki
机构信息
Safety Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, 1-1-1, Kazusakamatari, Kisarazu, Chiba 292-0818, Japan.
出版信息
Exp Toxicol Pathol. 2013 Jan;65(1-2):35-7. doi: 10.1016/j.etp.2011.05.006. Epub 2011 Jun 12.
Altered hepatocellular focus was histopathologically observed in the liver of a 6-week-old Sprague-Dawley rat. The hepatocytes within this lesion had diffusely eosinophilic cytoplasm with scattered basophilia and slightly enlarged nuclei with prominent nucleoli. Based on these cytological characteristics, the lesion of these hepatocytes was classified as an amphophilic focus. This is the first report to describe spontaneous amphophilic focus in a young rat.
在一只6周龄的斯普拉格-道利大鼠的肝脏中，通过组织病理学观察到肝细胞灶发生改变。该病变内的肝细胞具有弥漫性嗜酸性细胞质，伴有散在的嗜碱性，细胞核轻度增大，核仁突出。基于这些细胞学特征，这些肝细胞的病变被归类为嗜双色性病灶。这是首次报道在幼鼠中出现自发性嗜双色性病灶。
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