Achandira Udayakumar Muthappa, Pathare Anil V, Kindi Salam Al, Dennison David, Yahyaee Said Al
Sultan Qaboos University, College of Medicine and Health Sciences, PO Box 35, Muscat, 123, Oman.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.09.2008.0890. Epub 2009 Apr 28.
This report describes a case of acute lymphoblastic leukaemia in which isochromosome 9q (i(9q)) was the sole acquired cytogenetic abnormality. The Immunophenotype showed positivity for CD3, CD4, CD5, CD7, CD8, CD10, CD71, CD117 and TdT, consistent with T cell acute lymphoblastic leukaemia (ALL). The chromosomal analysis of bone marrow showed 46,XY,i(9)(q10) in all the metaphases analysed. The bone marrow morphology was ALL-L2 as per the French-American-British criteria. Isochromosomes are rare chromosomal abnormalities in childhood ALL and the effect of i(9q) is not well established. The patient's good response to therapy with normal cytogenetics within a month of induction, and disease-free survival after bone marrow transplant are indicative of a good prognosis in such cases.
本报告描述了一例急性淋巴细胞白血病病例，其中9号染色体长臂等臂染色体（i(9q)）是唯一获得性细胞遗传学异常。免疫表型显示CD3、CD4、CD5、CD7、CD8、CD10、CD71、CD117和TdT呈阳性，符合T细胞急性淋巴细胞白血病（ALL）。骨髓染色体分析显示，所有分析的中期细胞均为46,XY,i(9)(q10)。根据法国-美国-英国标准，骨髓形态学为ALL-L2。等臂染色体在儿童ALL中是罕见的染色体异常，i(9q)的影响尚未明确。患者在诱导治疗一个月内对正常细胞遗传学治疗反应良好，骨髓移植后无病生存，表明此类病例预后良好。
