Mneimneh Wadad Sami, Bonte Hélène, Bernheim Alain, Martin Antoine
Avicenne Hospital, Pathology, 125 Rue de Stalingrad, Bobigny, 93009, France.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.06.2008.0240. Epub 2009 Mar 2.
Myeloid sarcoma (MS) of the prostate is very uncommon with only 17 reported cases in the literature. Here, a singular case of a MS of the prostate discovered through investigations for urinary retention and revealing an acute leukaemia classified as an acute myeloid leukaemia (AML) with inversion 16 (inv16) according to the World Health Organization (WHO) classification (AML-M4 with inv16 in the French-American-British (FAB) classification) in a 65-year-old man is presented. None of the previously reported and reviewed cases of prostatic MS were of AML-M4 type. Moreover, a translocation t(3;7) was identified in our case. Such a translocation was recently described in some acute myeloid processes. MS treatment consists of combining surgical intervention and chemotherapy. Radiation therapy could be beneficial for the localised disease of the prostate. Allogenic haematopoietic stem cell transplantation is also a promising therapy for MS.
前列腺髓系肉瘤(MS)非常罕见,文献中仅报道了17例。本文介绍了一例通过因尿潴留进行检查而发现的前列腺MS病例,该病例显示一名65岁男性患有急性白血病,根据世界卫生组织(WHO)分类被归类为伴有16号染色体倒位(inv16)的急性髓系白血病(AML)(在法国-美国-英国(FAB)分类中为伴有inv16的AML-M4)。先前报道和回顾的前列腺MS病例均无AML-M4型。此外,在我们的病例中发现了一种t(3;7)易位。这种易位最近在一些急性髓系病变中有所描述。MS的治疗包括手术干预和化疗相结合。放射治疗可能对前列腺局限性疾病有益。异基因造血干细胞移植也是MS的一种有前景的治疗方法。