INRS-Institut Armand-Frappier, 531 Boul. des Prairies, Laval, Québec, Canada H7V 1B7.
Vet Microbiol. 2011 Nov 21;153(1-2):82-8. doi: 10.1016/j.vetmic.2011.05.043. Epub 2011 Jun 1.
During the course of infection, bacteria must coordinately regulate gene expression in response to environmental stimuli. The phosphate (Pho) regulon is controlled by the two component-regulatory system PhoBR. PhoBR is activated during starvation and regulates genes involved in phosphate homeostasis. Several studies have highlighted the importance of the Pho regulon in bacterial pathogenesis, showing how induction of PhoBR, in addition to regulating genes participating in phosphate metabolism, leads to modulation of many cellular processes. The pleiotropic effects of Pho regulon activation include attenuated virulence and alteration of many virulence traits, including adhesion to host cells and resistance to cationic antimicrobial peptides, acidity and oxidative stresses. This review provides an overview of the relationship between the Pho regulon and virulence in Escherichia coli and illustrates that, in addition to regulating phosphate homeostasis, the Pho regulon plays a key role in regulating stress responses and virulence.
在感染过程中，细菌必须协调基因表达以响应环境刺激。磷酸（Pho）调节子受双组分调节系统 PhoBR 控制。PhoBR 在饥饿时被激活，调节参与磷酸盐稳态的基因。几项研究强调了 Pho 调节子在细菌发病机制中的重要性，表明 PhoBR 的诱导除了调节参与磷酸盐代谢的基因外，还导致许多细胞过程的调节。Pho 调节子激活的多效性效应包括毒力减弱和许多毒力特征的改变，包括对宿主细胞的粘附和对阳离子抗菌肽、酸性和氧化应激的抗性。本综述概述了 Pho 调节子与大肠杆菌毒力之间的关系，并表明除了调节磷酸盐稳态外，Pho 调节子还在调节应激反应和毒力方面发挥关键作用。
