Ly Madani, Antoine Martine, André Fabrice, Callard Patrice, Bernaudin Jean-François, Diallo Dapa A
CHU du Point G, service d'hématologie et d'oncologie médicale, Bamako BP 333, Mali.
Bull Cancer. 2011 Jul;98(7):797-806. doi: 10.1684/bdc.2011.1392.
Breast cancer is the second most frequent cancer in Sub-Saharan African women with an incidence of 15-53 per 100,000 women. Using PubMed, we reviewed all the articles published on this topic between 1989 and 2009. Breast cancer is usually diagnosed in women younger than in developed countries (mean age: 42-53 years), with later stages (III or IV, i.e. with axillary nodes and distant metastases). Reported tumors are mostly invasive ductal carcinomas with aggressive characteristics: grade III histoprognosis, absence of hormonal receptors or HER2 expression. According to the new breast cancer classification, nearly half of these tumors should be classified as triple negative. However, studies are rare and require confirmation. In conclusion, data on epidemiology and biology of breast cancer in Sub-Saharan African women are still scarce and need more extensive studies. In these countries, the pattern of breast cancer will likely change in the future, according to the evolution of lifestyle namely urbanisation. There is a great need for commitment of research and clinical resources in Sub-Saharan Africa in order to develop specific strategies.
乳腺癌是撒哈拉以南非洲女性中第二常见的癌症，发病率为每10万名女性中有15 - 53例。我们利用PubMed检索了1989年至2009年间发表的关于该主题的所有文章。乳腺癌通常在比发达国家更年轻的女性中被诊断出来（平均年龄：42 - 53岁），且处于较晚阶段（III期或IV期，即伴有腋窝淋巴结和远处转移）。报告的肿瘤大多为具有侵袭性特征的浸润性导管癌：组织学预后为III级，缺乏激素受体或HER2表达。根据新的乳腺癌分类，这些肿瘤中近一半应被归类为三阴性。然而，相关研究很少且需要证实。总之，撒哈拉以南非洲女性乳腺癌的流行病学和生物学数据仍然匮乏，需要更广泛的研究。在这些国家，根据生活方式的演变即城市化，乳腺癌的模式未来可能会发生变化。撒哈拉以南非洲迫切需要投入研究和临床资源，以制定具体策略。
