Perinatal Institute, Division of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
J Clin Invest. 2011 Jul;121(7):2543-5. doi: 10.1172/JCI58704. Epub 2011 Jun 23.
The many challenges associated with lung transplantation provide a strong rationale for the development of cell- and tissue-based therapies for patients with respiratory failure caused by the loss of lung tissue that is associated with chronic pulmonary disease, injury, or resection. In this issue of the JCI, Chapman et al. take an important step forward in the development of regenerative medicine for the treatment of lung disease by identifying a novel integrin α6β4-expressing alveolar epithelial cell that serves as a multipotent progenitor during repair of the severely injured lung.
与肺移植相关的诸多挑战为细胞和组织疗法的发展提供了强有力的理论依据,这些疗法适用于因慢性肺部疾病、损伤或切除而导致肺组织丧失、进而引起呼吸衰竭的患者。在本期 JCI 中,Chapman 等人通过鉴定一种新型整合素 α6β4 表达的肺泡上皮细胞,该细胞在严重受损的肺修复过程中充当多能祖细胞,从而在肺病的再生医学治疗方面迈出了重要一步。