Nagata Nobuhiko, Wakamatsu Kentaro, Okamura Kyoko, Kajiki Akira, Kitahara Yoshinari
Second Department of Internal Medicine, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Kekkaku. 2011 Apr;86(4):453-7.
To prospectively investigate the relationship between the nutritional states of tuberculosis patients at the time of their admission to tuberculosis wards and their treatment outcomes.
We observed body mass index (BMI), peripheral blood lymphocyte count, serum albumin concentration, and induration size in the PPD skin test of a total of 107 tuberculosis patients after they had been newly admitted to NHO Omuta National Hospital during the period from Aug. 2004 to Jul. 2006. Based on these indices, the patients were divided into four groups according to their nutritional states: severely impaired, moderately impaired, mildly impaired or normal.
It was shown that the worse the nutritional state was on admission, the higher the mortality rate from all causes including tuberculosis. There has been no relapse case in patients from this group who have completed tuberculosis treatment despite their poor nutritional states at the start of the treatment.
This prospective study of the relationship between the nutritional states of tuberculosis patients on admission and their treatment outcomes reproduced the results obtained from a retrospective study that we had previously reported. The assessment method of the nutritional state that was used in our study was proven to be useful for predicting the prognosis of tuberculosis patients.
前瞻性调查肺结核患者入住结核病房时的营养状况与其治疗效果之间的关系。
我们观察了2004年8月至2006年7月期间新入住大牟田国立医院的107例肺结核患者的体重指数（BMI）、外周血淋巴细胞计数、血清白蛋白浓度以及PPD皮肤试验中的硬结大小。根据这些指标，将患者按营养状况分为四组：严重受损、中度受损、轻度受损或正常。
结果显示，入院时营养状况越差，包括结核病在内的各种原因导致的死亡率越高。该组中尽管治疗开始时营养状况不佳，但完成结核病治疗的患者无一例复发。
这项关于肺结核患者入院时营养状况与其治疗效果之间关系的前瞻性研究重现了我们之前报道的回顾性研究结果。我们研究中使用的营养状况评估方法被证明对预测肺结核患者的预后有用。
