去除多涎酸化神经细胞黏附分子可增强吗啡镇痛作用并干扰小鼠的耐受。
Removal of polysialylated neural cell adhesion molecule increases morphine analgesia and interferes with tolerance in mice.
机构信息
Department of Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
出版信息
Brain Res. 2011 Aug 2;1404:55-62. doi: 10.1016/j.brainres.2011.06.021. Epub 2011 Jun 14.
Abstract
Neurons that express high levels of polysialylated neural cell adhesion molecule (PSA-NCAM) in adult spinal substantia gelatinosa also express the μ-opioid receptor. While PSA removal from NCAM by spinal intrathecal injection of endoneuraminidase-N (endo-N) did not detectably change opioid receptor expression, morphine-induced analgesia was significantly increased. This analgesic strengthening was detected as early as 15 min after endo-N treatment and persisted for at least 7 days. In addition, the tolerance that develops with chronic morphine treatment was overcome in the absence of PSA. Interestingly, the same effects on analgesia and tolerance were also produced by selective deletion of the NCAM-180 isoform.
摘要
成年脊髓胶状质中表达高水平多聚唾液酸神经细胞黏附分子（PSA-NCAM）的神经元也表达μ-阿片受体。虽然通过鞘内注射神经氨酸酶-N（endo-N）从 NCAM 上去除 PSA 并没有明显改变阿片受体的表达，但吗啡诱导的镇痛作用显著增强。这种镇痛增强早在 endo-N 处理后 15 分钟就被检测到，并持续至少 7 天。此外，在没有 PSA 的情况下，慢性吗啡治疗产生的耐受也被克服了。有趣的是，选择性删除 NCAM-180 同工型也产生了相同的镇痛和耐受效果。
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