基因修饰间充质干细胞用于改善胰岛移植。
Genetically modified mesenchymal stem cells for improved islet transplantation.
机构信息
Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
出版信息
Mol Pharm. 2011 Oct 3;8(5):1458-70. doi: 10.1021/mp200135e. Epub 2011 Jul 7.
Abstract
The use of adult stem cells for therapeutic purposes has met with great success in recent years. Among several types of adult stem cells, mesenchymal stem cells (MSCs) derived from bone marrow (BM) and other sources have gained popularity for basic research and clinical applications because of their therapeutic potential in treating a variety of diseases. Because of their tissue regeneration potential and immune modulation effect, MSCs were recently used as cell-based therapy to promote revascularization, increase pancreatic β-cell proliferation, and avoid allograft rejection in islet transplantation. Taking advantage of the recent progress in gene therapy, genetically modified MSCs can further enhance and expand the therapeutic benefit of primary MSCs while retaining their stem-cell-like properties. This review aims to gain a thorough understanding of the current obstacles to successful islet transplantation and discusses the potential role of primary MSCs before or after genetic modification in islet transplantation.
摘要
近年来，成体干细胞在治疗方面的应用取得了巨大成功。在几种成体干细胞中，骨髓（BM）和其他来源的间充质干细胞（MSCs）因其在治疗多种疾病方面的治疗潜力，在基础研究和临床应用中受到了广泛关注。由于其组织再生潜力和免疫调节作用，MSCs 最近被用作基于细胞的疗法，以促进血管生成、增加胰岛 β 细胞增殖，并避免胰岛移植中的同种异体排斥反应。利用基因治疗的最新进展，经过基因修饰的 MSCs 可以在保留其干细胞特性的同时，进一步增强和扩大原代 MSCs 的治疗益处。本综述旨在深入了解胰岛移植成功的当前障碍，并讨论在基因修饰前后，原代 MSCs 在胰岛移植中的潜在作用。
相似文献
1
Genetically modified mesenchymal stem cells for improved islet transplantation.基因修饰间充质干细胞用于改善胰岛移植。
Mol Pharm. 2011 Oct 3;8(5):1458-70. doi: 10.1021/mp200135e. Epub 2011 Jul 7.
2
Co-transplantation of Xenogeneic Bone Marrow-derived Mesenchymal Stem Cells Alleviates Rejection of Pancreatic Islets in Non-obese Diabetic Mice.异种骨髓来源间充质干细胞共移植减轻非肥胖糖尿病小鼠胰岛的排斥反应
Transplant Proc. 2017 May;49(4):902-905. doi: 10.1016/j.transproceed.2017.01.064.
3
Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site.自体间充质干细胞的共移植可延缓胰岛同种异体移植排斥反应，并产生局部免疫豁免部位。
Acta Diabetol. 2015 Oct;52(5):917-27. doi: 10.1007/s00592-015-0735-y. Epub 2015 Mar 27.
4
Mesenchymal stem cells prevent acute rejection and prolong graft function in pancreatic islet transplantation.间充质干细胞可预防胰岛移植的急性排斥反应并延长移植物功能。
Diabetes Technol Ther. 2010 Jun;12(6):435-46. doi: 10.1089/dia.2009.0154.
5
Potential of mesenchymal stromal cells for improving islet transplantation outcomes.间充质基质细胞在改善胰岛移植效果方面的潜力。
Curr Opin Pharmacol. 2018 Dec;43:34-39. doi: 10.1016/j.coph.2018.07.011. Epub 2018 Aug 10.
6
Reduction of marginal mass required for successful islet transplantation in a diabetic rat model using adipose tissue-derived mesenchymal stromal cells.利用脂肪组织来源的间充质基质细胞减少糖尿病大鼠模型中胰岛移植成功所需的边缘质量。
Cytotherapy. 2018 Sep;20(9):1124-1142. doi: 10.1016/j.jcyt.2018.06.001. Epub 2018 Jul 29.
7
Mesenchymal stem cells facilitate the induction of mixed hematopoietic chimerism and islet allograft tolerance without GVHD in the rat.间充质干细胞有助于在大鼠中诱导混合造血嵌合体和胰岛同种异体移植耐受，且不发生移植物抗宿主病。
Am J Transplant. 2007 Feb;7(2):336-46. doi: 10.1111/j.1600-6143.2006.01643.x.
8
[The effect of co-transplantation of bone marrow-derived mesenchymal stem cells and islet on maturation and function of bone marrow-derived dendritic cells in recipient mice].骨髓间充质干细胞与胰岛共移植对受体小鼠骨髓来源树突状细胞成熟及功能的影响
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Jul;26(7):646-9.
9
Co-combination of islets with bone marrow mesenchymal stem cells promotes angiogenesis.胰岛与骨髓间充质干细胞联合促进血管生成。
Biomed Pharmacother. 2016 Mar;78:156-164. doi: 10.1016/j.biopha.2016.01.007. Epub 2016 Jan 29.
10
Mesenchymal stem cells and islet cotransplantation in diabetic rats: improved islet graft revascularization and function by human adipose tissue-derived stem cells preconditioned with natural molecules.间质干细胞与胰岛共移植于糖尿病大鼠：经天然分子预处理的人脂肪组织来源干细胞改善胰岛移植物再血管化和功能。
Cell Transplant. 2012;21(12):2771-81. doi: 10.3727/096368912X637046. Epub 2012 Apr 2.
引用本文的文献
1
Local Immunomodulatory Strategies to Prevent Allo-Rejection in Transplantation of Insulin-Producing Cells.局部免疫调节策略预防胰岛素分泌细胞移植中的同种异体排斥反应。
Adv Sci (Weinh). 2021 Sep;8(17):e2003708. doi: 10.1002/advs.202003708. Epub 2021 Jul 14.
2
Immunomodulatory effects of OX40Ig gene-modified adipose tissue-derived mesenchymal stem cells on rat kidney transplantation.OX40Ig基因修饰的脂肪组织来源间充质干细胞对大鼠肾移植的免疫调节作用
Int J Mol Med. 2017 Jan;39(1):144-152. doi: 10.3892/ijmm.2016.2808. Epub 2016 Nov 21.
3
From Beta cell replacement to beta cell regeneration: implications for antidiabetic therapy.从β细胞替代到β细胞再生：对糖尿病治疗的启示。
J Diabetes Sci Technol. 2014 Nov;8(6):1221-6. doi: 10.1177/1932296814540611. Epub 2014 Jun 22.
4
Conditional expression of the type 2 angiotensin II receptor in mesenchymal stem cells inhibits neointimal formation after arterial injury.间充质干细胞中血管紧张素II 2型受体的条件性表达可抑制动脉损伤后的内膜增生。
J Cardiovasc Transl Res. 2014 Oct;7(7):635-43. doi: 10.1007/s12265-014-9576-2. Epub 2014 Aug 14.
5
Role of notch signaling in the maintenance of human mesenchymal stem cells under hypoxic conditions.Notch信号通路在低氧条件下对人骨髓间充质干细胞的维持作用。
Stem Cells Dev. 2014 Sep 15;23(18):2211-24. doi: 10.1089/scd.2013.0642. Epub 2014 Aug 5.
6
Genetically modified human bone marrow derived mesenchymal stem cells for improving the outcome of human islet transplantation.用于改善人胰岛移植结局的基因修饰人骨髓间充质干细胞。
PLoS One. 2013 Oct 29;8(10):e77591. doi: 10.1371/journal.pone.0077591. eCollection 2013.
7
Tightly regulated and homogeneous transgene expression in human adipose-derived mesenchymal stem cells by lentivirus with tet-off system.通过四环素调控的慢病毒系统实现人脂肪间充质干细胞中紧密调控且均一的转基因表达。
PLoS One. 2013 Jun 12;8(6):e66274. doi: 10.1371/journal.pone.0066274. Print 2013.
8
Third-party mesenchymal stem cells improved human islet transplantation in a humanized diabetic mouse model.第三方间充质干细胞改善了人源化糖尿病小鼠模型中的胰岛移植。
Mol Ther. 2013 Sep;21(9):1778-86. doi: 10.1038/mt.2013.147. Epub 2013 Jun 14.
9
Combining stem cells and genes for effective therapeutics.将干细胞与基因相结合以实现有效的治疗。
Mol Pharm. 2011 Oct 3;8(5):1443-5. doi: 10.1021/mp200437m.
本文引用的文献
1
Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia.慢病毒载体介导的间充质干细胞修饰与体外缺血模型中细胞存活的增强。
Stem Cell Res Ther. 2011 Mar 7;2(2):12. doi: 10.1186/scrt53.
2
Interleukin (IL)-10 induced by CD11b(+) cells and IL-10-activated regulatory T cells play a role in immune modulation of mesenchymal stem cells in rat islet allografts.CD11b(+) 细胞诱导的白细胞介素 (IL)-10 和 IL-10 激活的调节性 T 细胞在大鼠胰岛同种异体移植物中调节间充质干细胞的免疫中发挥作用。
Mol Med. 2011;17(7-8):697-708. doi: 10.2119/molmed.2010.00098. Epub 2011 Feb 25.
3
Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice.间质干细胞共移植维持小鼠胰岛的组织和形态。
Diabetologia. 2011 May;54(5):1127-35. doi: 10.1007/s00125-011-2053-4. Epub 2011 Jan 26.
4
Characterization of immortalized mesenchymal stem cells derived from foetal porcine pancreas.猪胎儿胰腺来源永生化间充质干细胞的鉴定。
Cell Prolif. 2011 Feb;44(1):19-32. doi: 10.1111/j.1365-2184.2010.00714.x.
5
Human BM stem cells initiate angiogenesis in human islets in vitro.人骨髓基质干细胞在体外诱导人胰岛血管生成。
Bone Marrow Transplant. 2011 Aug;46(8):1128-37. doi: 10.1038/bmt.2010.278. Epub 2010 Dec 6.
6
Mesenchymal stem cells protect islets from hypoxia/reoxygenation-induced injury.间充质干细胞可保护胰岛免受低氧/复氧诱导的损伤。
Cell Biochem Funct. 2010 Dec 2;28(8):637-43. doi: 10.1002/cbf.1701.
7
Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility.自体间充质基质细胞与肾移植：安全性和临床可行性的初步研究。
Clin J Am Soc Nephrol. 2011 Feb;6(2):412-22. doi: 10.2215/CJN.04950610. Epub 2010 Oct 7.
8
Effects of recombinant adeno-associated viral vectors on angiopoiesis and osteogenesis in cultured rabbit bone marrow stem cells via co-expressing hVEGF and hBMP genes: a preliminary study in vitro.重组腺相关病毒载体通过共表达 hVEGF 和 hBMP 基因对培养兔骨髓干细胞血管生成和成骨作用的影响：体外初步研究。
Tissue Cell. 2010 Oct;42(5):314-21. doi: 10.1016/j.tice.2010.07.007.
9
XIAP gene expression protects β-cells and human islets from apoptotic cell death.XIAP 基因表达可保护β细胞和人胰岛免受细胞凋亡。
Mol Pharm. 2010 Oct 4;7(5):1655-66. doi: 10.1021/mp100070j. Epub 2010 Aug 2.
10
Mesenchymal stem cells enhance allogeneic islet engraftment in nonhuman primates.间充质干细胞增强非人类灵长类动物同种异体胰岛移植物的植入。
Diabetes. 2010 Oct;59(10):2558-68. doi: 10.2337/db10-0136. Epub 2010 Jul 9.
Zotero 插件