成人颅咽管瘤囊液引流术后分次立体定向放疗的初步结果。
Preliminary results of fractionated stereotactic radiotherapy after cyst drainage for craniopharyngioma in adults.
机构信息
Department of Radiology, Tokyo Medical University Hospital, Tokyo, Japan.
出版信息
Int J Radiat Oncol Biol Phys. 2012 Mar 15;82(4):1356-60. doi: 10.1016/j.ijrobp.2011.05.014. Epub 2011 Jun 28.
PURPOSE
To retrospectively evaluate the effectiveness of fractionated stereotactic radiotherapy (FSRT) for craniopharyngioma.
METHODS AND MATERIALS
Between 1999 and 2005, 16 patients with craniopharyngioma were referred to Tokyo Medical University Hospital. They received FSRT alone after histologic confirmation by needle biopsy and underwent cyst drainage via endoscopy. The median prescription dose fraction was 30 Gy in six fractions. All patients except 1 were followed up until December 2009 or death.
RESULTS
The median follow-up period was 52 months (range, 4-117 months). Of the 17 patients, 3 experienced recurrence 4 to 71 months after FSRT. The 3-year local control rate was 82.4%. One patient died of thyroid cancer, and the 3-year survival rate was 94.1%. Eight patients had improved visual fields at a median of 2.5 months after FSRT, but hormonal functions did not improve in any patient.
CONCLUSIONS
FSRT after cyst drainage seems to be safe and effective for patients with craniopharyngiomas, and it may be a safe alternative to surgery.
目的
回顾性评估分次立体定向放射治疗（FSRT）颅咽管瘤的疗效。
方法和材料
1999 年至 2005 年间，16 例颅咽管瘤患者经组织学证实为颅咽管瘤后，行 FSRT 联合内镜下囊肿引流术。中位处方剂量为 30 Gy，共 6 次。除 1 例患者外，其余患者均随访至 2009 年 12 月或死亡。
结果
中位随访时间为 52 个月（范围，4-117 个月）。17 例患者中，3 例在 FSRT 后 4 至 71 个月复发。3 年局部控制率为 82.4%。1 例患者死于甲状腺癌，3 年生存率为 94.1%。8 例患者在 FSRT 后 2.5 个月时视野改善，而患者的激素功能没有任何改善。
结论
FSRT 联合内镜下囊肿引流术治疗颅咽管瘤安全有效，可作为手术的安全替代疗法。
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