Berlin Joshua M, Eisenberg David P, Berlin Mindy B, Sarro Robert A, Leeman Douglas R, Fein Howard
Dermatology Associates, PA, of the Palm Beaches, Boynton Beach, FL 33437, USA.
J Drugs Dermatol. 2011 Jul;10(7):718-22.
Senile purpura is a common, chronic skin condition affecting more than 10 percent of individuals over the age of 50. Despite being a benign condition, the continual development of purpura lesions in afflicted patients is frequently a source of significant visual and social concern. To date, there are no known effective treatments for this condition.
To evaluate the efficacy of a novel nutraceutical citrus bioflavonoid blend in improving the skin's appearance in patients with senile purpura.
A six-week, randomized, multicenter, placebo-controlled, double-blind study was conducted to determine whether a uniquely formulated, oral citrus bioflavonoid supplement could treat active lesions of senile purpura while preventing new lesions from arising. Seventy patients with senile purpura were enrolled and 67 completed the study. Subjects were randomized into two groups receiving either a citrus bioflavonoid blend or placebo medication, which was taken orally twice daily for six weeks. Clinical evaluations were performed by blinded investigators at two locations.
A statistically significant reduction in the number of new purpura lesions in the skin area undergoing clinical study was documented. At the end of six weeks, the citrus bioflavonoid blend treated group showed a 50 percent reduction in purpura lesions from baseline. Patient self-assessment of the effectiveness of the medication echoed the results of an investigator global assessment with a statistically significant improvement in the skin's appearance noted by the patients receiving the active medication. No adverse effects were noted by either the patients or investigators.
This new treatment appears to both safely and effectively diminish skin bruising in patients with senile purpura.
老年性紫癜是一种常见的慢性皮肤疾病，影响着超过10%的50岁以上人群。尽管它是一种良性疾病，但患病患者紫癜皮损的持续发展常常是严重的视觉和社交问题的根源。迄今为止，尚无已知的有效治疗方法。
评估一种新型营养保健品柑橘生物类黄酮混合物改善老年性紫癜患者皮肤外观的疗效。
进行了一项为期六周的随机、多中心、安慰剂对照、双盲研究，以确定一种独特配方的口服柑橘生物类黄酮补充剂是否能治疗老年性紫癜的活动性皮损，同时防止新皮损出现。招募了70例老年性紫癜患者，67例完成了研究。受试者被随机分为两组，分别接受柑橘生物类黄酮混合物或安慰剂药物治疗，每天口服两次，持续六周。由两个地点的盲法研究者进行临床评估。
临床研究的皮肤区域新紫癜皮损数量有统计学意义的减少。六周结束时，柑橘生物类黄酮混合物治疗组的紫癜皮损较基线减少了50%。患者对药物有效性的自我评估与研究者整体评估结果一致，接受活性药物治疗的患者皮肤外观有统计学意义的改善。患者和研究者均未注意到不良反应。
这种新疗法似乎能安全有效地减少老年性紫癜患者的皮肤瘀斑。
