Department of Adult Surgery, KASSAB's Institute Kassar Said, university Tunis el manar II, 2010 Mannouba Tunisia.
Orthop Traumatol Surg Res. 2011 Sep;97(5):520-6. doi: 10.1016/j.otsr.2011.03.019. Epub 2011 Jun 30.
As osteoclast, giant cell tumors express calcitonin receptors. The aim of this paper is to assess treatment using salmon calcitonin after curettage.
We retrospectively reviewed 25 patients with giant cell tumor of the appendicular skeleton treated with a single protocol of calcitonin administration following curettage in order to assess the effectiveness of calcitonin in reducing the rate of local recurrence.
The mean duration follow-up was 68 months. Thirteen patients (52%) had local recurrence. Eight of them were treated successfully after repeated curettage and calcitonin. Four patients had bone resection and one patient had curettage and cement filling. All patients with cavity left empty had ossified and the functional score as assessed by the MSTS score was 28.02/30.
This study suggests that the use of calcitonin as adjuvant is not effective and that filling agents are not required after curettage of giant cell tumors.
Level 4.
破骨细胞样巨细胞瘤表达降钙素受体。本文旨在评估刮除术后鲑鱼降钙素治疗的效果。
我们回顾性分析了 25 例采用刮除术后单一降钙素给药方案治疗的四肢骨附属巨细胞瘤患者，以评估降钙素在降低局部复发率方面的有效性。
平均随访时间为 68 个月。13 例（52%）患者发生局部复发。其中 8 例经反复刮除和降钙素治疗后成功治愈。4 例患者行骨切除，1 例患者行刮除和骨水泥填充。所有空洞未填充的患者均有骨化，MSTS 评分评估的功能评分得分为 28.02/30。
本研究表明，降钙素作为辅助治疗无效，刮除巨细胞瘤后不需要填充剂。
4 级。
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