Department of Microbiology, Hospital Sant Joan de Deu and University of Barcelona, Esplugues, Spain.
Clin Microbiol Infect. 2011 Sep;17(9):1441-4. doi: 10.1111/j.1469-0691.2011.03526.x. Epub 2011 Jul 5.
Fifty-six isolates of serotype 1 were identified during a 20-year prospective study (1989-2008), including all children with culture-proven invasive pneumococcal disease (IPD) admitted to a children's hospital in Barcelona. Forty-eight of them (85.7%) were in children aged >2 years. Complicated pneumonia (n = 28) and non-complicated pneumonia (n = 20) were the main clinical presentations. The frequency of serotype 1 IPD increased from 1999-2003 to 2004-2008: 1.2 to 4.4 episodes/100 000 children (p <0.001). The ST306 clone were identified in 70.4% of isolates. As IPD caused by serotype 1 is mainly detected in older children, a vaccination programme for children >2 years should be considered.
在一项为期 20 年的前瞻性研究（1989-2008 年）中鉴定了 56 株 1 型血清型分离株，包括巴塞罗那一家儿童医院所有经培养证实的侵袭性肺炎球菌病（IPD）患儿。其中 48 株（85.7%）患儿年龄>2 岁。主要临床表现为复杂性肺炎（n=28）和非复杂性肺炎（n=20）。1 型 IPD 的发病率从 1999-2003 年至 2004-2008 年增加：每 100000 名儿童中 1.2 至 4.4 例（p<0.001）。70.4%的分离株为 ST306 克隆。由于由 1 型引起的 IPD 主要在较大儿童中检测到，因此应考虑为>2 岁的儿童接种疫苗。
