Department of Sensitive Organs, Policlinic Umberto I, Sapienza University, Rome, Italy.
J Reprod Immunol. 2011 Sep;91(1-2):103-7. doi: 10.1016/j.jri.2011.03.010. Epub 2011 Jul 13.
Several studies have reported that fetuses with intrauterine growth restriction (IUGR) and infants with low birth weight present increased intima/media thickness (aIMT) of the abdominal aorta wall compared with fetuses and infants appropriate for gestational age (AGA). Evidence suggested that aIMT might be related to inflammation, probably indicating a very early stage of future adulthood disease, such as atherosclerosis. We aimed to investigate histological findings in the abdominal aorta wall of one IUGR stillbirth in which ultrasound had detected aIMT. Microscopy observations of the abdominal aorta wall confirmed the intima thickening and detected condensation of the elastic fibers forming an evident internal elastic membrane and presence of inflammatory elements, such as macrophages, activated endothelial cells, and fibroblastoid cells. The present study highlights that IUGR associated with aIMT is related to inflammation, which might represent a very early sign of future adult lesions.
多项研究报告称，与胎龄适当的胎儿和婴儿相比，宫内生长受限（IUGR）的胎儿和低出生体重的婴儿其腹主动脉壁的内中膜厚度（aIMT）增加。有证据表明，aIMT 可能与炎症有关，可能预示着未来成年疾病的早期阶段，如动脉粥样硬化。我们旨在研究超声检测到 aIMT 的一例 IUGR 死胎的腹主动脉壁的组织学发现。腹主动脉壁的显微镜观察证实了内膜增厚，并检测到弹性纤维的凝聚，形成明显的内弹性膜和炎症细胞的存在，如巨噬细胞、活化的内皮细胞和成纤维细胞样细胞。本研究强调，与 aIMT 相关的 IUGR 与炎症有关，这可能是未来成年病变的早期迹象。
