多发性硬化症中非 HLA 易感性基因对疾病进展无影响。
No influence on disease progression of non-HLA susceptibility genes in MS.
机构信息
The Multiple Sclerosis Research group, Centre for Molecular Medicine, Department of Clinical neuroscience, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Neuroimmunol. 2011 Aug 15;237(1-2):98-100. doi: 10.1016/j.jneuroim.2011.05.003. Epub 2011 Jul 13.
Recently, several non-HLA loci have been shown to be convincingly associated with Multiple Sclerosis (MS) susceptibility, assumingly indicating important pathways in the pathogenesis. A genotype influence on disease outcome measures by these genes would support a role of these pathways in ongoing tissue damage. Here, however, we report a consistent dissociation between causation and progression for five non-HLA genotypes (IL7R, IL2RA, CLEC16A, CD226 and SH2B3) in 1776 Scandinavian MS patients.
最近，有几个非 HLA 基因座被证明与多发性硬化症（MS）易感性密切相关，这表明这些基因座在发病机制中具有重要作用。这些基因对疾病结局的基因型影响支持这些途径在持续的组织损伤中的作用。然而，在这里，我们在 1776 例斯堪的纳维亚 MS 患者中报告了五个非 HLA 基因型（IL7R、IL2RA、CLEC16A、CD226 和 SH2B3）与病因和进展之间的一致分离。
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