增加男孩接种当前人乳头瘤病毒疫苗计划的增量影响：群体免疫的作用。

Incremental impact of adding boys to current human papillomavirus vaccination programs: role of herd immunity.

机构信息

Unité de Recherche en Santé des Populations, Centre de Recherche Fonds de la Recherche en Santé du Québec du Centre Hospitalier affilié Universitaire de Québec, Canada.

出版信息

J Infect Dis. 2011 Aug 1;204(3):372-6. doi: 10.1093/infdis/jir285.

DOI:10.1093/infdis/jir285

PMID:21742835

Abstract

Our aim was to examine the potential incremental impact of vaccinating boys against human papillomavirus (HPV) on vaccine-type infection in females and males, using an individual-based HPV transmission-dynamic model. Under base assumptions (vaccine efficacy = 99%, duration of protection = 20 years, coverage = 70%), vaccinating 12-year-old boys, in addition to girls, resulted in an incremental reduction in HPV-16/18 (HPV-6/11) incidence over 70 years of 16% (3%) in females and 23% (4%) in males. The benefit of vaccinating boys decreased with improved vaccination coverage in girls. Given the important predicted herd immunity impact of vaccinating girls under moderate to high vaccine coverage, the potential incremental gains of vaccinating boys are limited.

摘要

我们的目的是利用 HPV 传播动力学模型，评估男孩接种 HPV 疫苗对女性和男性 HPV 疫苗型感染的潜在增量影响。在基本假设条件下（疫苗效力=99%，保护持续时间=20 年，接种率=70%），除了女孩外，12 岁男孩接种疫苗，可使 HPV-16/18（HPV-6/11）70 年累计发病率降低 16%（3%）在女性和 23%（4%）在男性中。随着女孩接种率的提高，男孩接种疫苗的好处会减少。鉴于在中高疫苗接种率下，接种女孩可产生重要的预测群体免疫效应，因此男孩接种疫苗的潜在增量收益有限。