产后氨溴索在预防和治疗早产儿呼吸窘迫综合征中的作用评估
Evaluation of the role of postnatal ambroxol in the prevention and treatment of respiratory distress syndrome in preterm neonates.
作者信息
Elsayed Hesham F, Elkhaiouby Muhammed I, Elsharkawey Sunia M, Elnemr Muna A
机构信息
The institution where the research was performed: Neonatal Intensive Care Unit, Pediatric Department, Suez Canal University Hospital, EGYPT.
出版信息
Sultan Qaboos Univ Med J. 2006 Dec;6(2):41-6.
OBJECTIVE
to study the effect of the postnatal administration of Ambroxol in the prevention of respiratory distress syndrome in preterm neonates at risk and on the severity of the disease in those neonates already suffering from it.
METHODS
the study was a randomized clinical trial performed on 120 preterm neonates admitted to the neonatal unit of the Suez Canal University Hospital, Egypt, with gestational age of 28 to 34 weeks. It was performed in the period from September 2001 through March 2003. Half of the enrolled neonates received intravenous ambroxol (20 mg/kg/d), while the control group received the routine management of prematurity and a placebo.
RESULTS
Ambroxol decreased the incidence of Respiratory Distress Syndrome (RDS), improved the gas exchange, and decreased Continious Positive Airway pressure (CPAP) pressure, the length of mechanical ventilation and also the mortality rate.
CONCLUSION
the study concluded that Ambroxol reduced the incidence of this disease in preterm neonates at risk of developing it, and improved the clinical course of RDS.
目的
研究氨溴索产后给药对有风险的早产儿预防呼吸窘迫综合征的效果以及对已患该病的早产儿疾病严重程度的影响。
方法
该研究是一项随机临床试验，对120名入住埃及苏伊士运河大学医院新生儿科、胎龄为28至34周的早产儿进行。研究于2001年9月至2003年3月期间进行。一半入选新生儿接受静脉注射氨溴索（20毫克/千克/天），而对照组接受早产儿常规管理及安慰剂。
结果
氨溴索降低了呼吸窘迫综合征（RDS）的发生率，改善了气体交换，降低了持续气道正压通气（CPAP）压力、机械通气时间以及死亡率。
结论
该研究得出结论，氨溴索降低了有发生该病风险的早产儿中这种疾病的发生率，并改善了呼吸窘迫综合征的临床病程。
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