Jiang Y B, Wang Y Z, Zhao J, Marchal G, Wang Y X, Shen Y L, Xing S Z, Zhang X Y, Baert A L
Department of Radiologic Pathology, Beijing Institute of Traumatology and Orthopaedics, Peoples Republic of China.
Invest Radiol. 1990 Nov;25(11):1188-96.
Because the pathogenesis of osteosclerosis in hypervitaminosis D is still not well elucidated, the authors experimentally studied hypervitaminosis D3 in 66 rabbits by injecting different doses of vitamin D3. Contact radiographs of bone specimens showed various signs of osteosclerosis, including dense epiphyses and metaphyses, thickened bony articular surfaces, dense metaphyseal bands, modeling defects at the metaphysis, and dense and thickened cortical bone. The corresponding pathologic sections showed that conspicuous metastatic calcification coated the trabeculae and filled bone marrow cavity and caverns in the original but porotic cortical and periosteal new bone. Rather than being resorbed, the metastatic calcifications were embedded in a thick layer of newly formed bone 6 to 14 weeks after vitamin D3 withdrawal. This study suggests that in hypervitaminosis D3, the osteoblasts and bone marrow undergo degeneration, leading to necrosis and calcification. After vitamin D3 withdrawal, osteoblasts reappear and become overactive, leading to overossification.
由于维生素D过多症中骨硬化的发病机制仍未完全阐明，作者通过给66只兔子注射不同剂量的维生素D3，对维生素D3过多症进行了实验研究。骨标本的接触X线片显示了骨硬化的各种迹象，包括骨骺和干骺端致密、骨关节面增厚、干骺端带致密、干骺端塑形缺陷以及皮质骨致密增厚。相应的病理切片显示，明显的转移性钙化覆盖了小梁，并填充了原来疏松的皮质骨和骨膜新骨中的骨髓腔和空洞。维生素D3停用6至14周后，转移性钙化没有被吸收，而是嵌入了一层厚厚的新形成的骨中。这项研究表明，在维生素D3过多症中，成骨细胞和骨髓会发生退变，导致坏死和钙化。维生素D3停用后，成骨细胞重新出现并变得过度活跃，导致过度骨化。
