Department of Infection and Host Defense, Shinshu University, Graduate School of Medicine, Matsumoto 390-8621, Japan.
Pediatr Rheumatol Online J. 2011 Jul 13;9(1):15. doi: 10.1186/1546-0096-9-15.
Systemic juvenile idiopathic arthritis (sJIA) is a systemic inflammatory disease characterized by arthritis, spiking fever and a skin rash that is frequently complicated by macrophage activation syndrome (MAS), a life-threatening disorder. We report a 22-month-old girl with sJIA who developed severe MAS but was successfully treated with corticosteroids, cyclosporin A, and non-steroidal anti-inflammatory drugs by monitoring serum IL-18 levels. IL-18 is an extremely useful cytokine for monitoring the activity of sJIA and MAS, and serum IL-18 can be used as an indicator for the effectiveness of treatment and the decision to discontinue therapy.
全身性幼年特发性关节炎（sJIA）是一种全身性炎症性疾病，其特征为关节炎、高热和皮疹，常伴有巨噬细胞活化综合征（MAS），这是一种危及生命的疾病。我们报告了一例 sJIA 患儿，她患有严重的 MAS，但通过监测血清 IL-18 水平，使用皮质类固醇、环孢素 A 和非甾体抗炎药成功治疗。IL-18 是监测 sJIA 和 MAS 活动的一种非常有用的细胞因子，血清 IL-18 可作为治疗效果和停药决策的指标。
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