Costa I R, Silva R C P C, Frare A B, Silva C T X, Bordin B M, Souza S R, Ribeiro Júnior C L, Moura K K V O
Núcleo de Pesquisas Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
Genet Mol Res. 2011 Jul 6;10(3):1364-70. doi: 10.4238/vol10-3gmr913.
We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and analyzed on a 2% agarose gel stained with ethidium bromide. The frequency of polymorphic genotypes (A1/A2 and A2/A2) was significantly higher in patients with endometriosis (33%) than in the control group (16%). We conclude that there is a significant correlation between PROGINS polymorphism and endometriosis.
我们研究了子宫内膜异位症与孕激素受体基因（PROGINS）多态性之间的可能联系。子宫内膜异位症组由54例经腹腔镜诊断为子宫内膜异位症的患者组成，对照组包括44名无子宫内膜异位症的女性。通过聚合酶链反应确定PROGINS多态性的基因型（A1/A1、A1/A2和A2/A2），并在经溴化乙锭染色的2%琼脂糖凝胶上进行分析。子宫内膜异位症患者中多态基因型（A1/A2和A2/A2）的频率（33%）显著高于对照组（16%）。我们得出结论，PROGINS多态性与子宫内膜异位症之间存在显著相关性。
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