2 型糖尿病患者 δ-氨基乙酰丙酸脱水酶活性及其与血脂谱和氧化应激的关系。
δ-Aminolevulinate dehydratase activity in type 2 diabetic patients and its association with lipid profile and oxidative stress.
机构信息
Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil.
出版信息
Clin Biochem. 2011 Sep;44(13):1105-1109. doi: 10.1016/j.clinbiochem.2011.06.980. Epub 2011 Jul 6.
OBJECTIVES
To investigate the activity of δ-Aminolevulinate dehydratase (δ-ALA-D) and its possible relationship with oxidative status, lipid profile, body mass index (BMI) in type 2 diabetics (DM2) patients.
DESIGN AND METHODS
δ-ALA-D activity and reactivation index, as well as markers of oxidative stress and biochemical and anthropometrics parameters were determined in DM2 patients (n = 63) and controls (n = 63).
RESULTS
There was a decreased δ-ALA-D activity and a higher reactivation index (p<0.05) in DM2 patients besides an elevated level of oxidative stress. Disturbances on lipid profile were related to the enzymatic activity and BMI also was correlated with oxidative level in DM2 patients (p<0.05).
CONCLUSION
There is an association between oxidative stress, abnormalities on lipid profile, distribution of body fat and δ-ALA-D activity inhibition as well as the enzyme is more oxidized in the DM2 suggesting that it would be a good biomarker for assessing prejudice in chronic metabolic processes.
目的
研究 δ-氨基酮戊酸脱水酶（δ-ALA-D）的活性及其与氧化状态、血脂谱、体重指数（BMI）的可能关系在 2 型糖尿病（DM2）患者中。
设计和方法
在 DM2 患者（n=63）和对照组（n=63）中测定了 δ-ALA-D 活性和再激活指数，以及氧化应激和生化及人体测量参数的标志物。
结果
DM2 患者的 δ-ALA-D 活性降低，再激活指数升高（p<0.05），氧化应激水平升高。血脂谱异常与酶活性有关，BMI 也与 DM2 患者的氧化水平相关（p<0.05）。
结论
氧化应激、血脂谱异常、体脂分布与 δ-ALA-D 活性抑制之间存在关联，并且该酶在 DM2 中更为氧化，提示它可能是评估慢性代谢过程中偏见的良好生物标志物。
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