通过酰胺键连接的新霉胺和 2-脱氧链霉胺缀合物。
Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond.
机构信息
Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, United States.
出版信息
Bioorg Med Chem Lett. 2011 Aug 15;21(16):4713-5. doi: 10.1016/j.bmcl.2011.06.084. Epub 2011 Jun 29.
An amino-functionalized 2-deoxystreptamine (2-DOS) mimic was conjugated by an amide bond to a neamine moiety containing a carboxylic acid in ring II. A library of A-site RNA and its mutants was prepared to examine RNA binding characteristics of the additional 2-DOS moiety attached to neamine. The 2-DOS mimic conjugated to the neamine increased binding affinity up to 200-folds compared to that of neamine. The conjugate binds to native A-site RNA and its mutants with up to 6-fold difference in sequence selectivity.
一个氨基功能化的 2-脱氧链霉胺（2-DOS）类似物通过酰胺键连接到含有第二个环中的羧酸的新霉素部分。 制备了 A 位 RNA 文库及其突变体，以检查连接到新霉素的额外 2-DOS 部分的 RNA 结合特性。 与新霉素相比，连接到新霉素的 2-DOS 类似物增加了高达 200 倍的结合亲和力。 该缀合物与天然 A 位 RNA 及其突变体结合，在序列选择性方面差异高达 6 倍。
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