[肝硬化大鼠的胆红素和胆汁酸代谢]

[Bilirubin and bile acid metabolism in cirrhotic rats].

作者信息

Huang Y

出版信息

Zhonghua Yi Xue Za Zhi. 1990 Oct;70(10):567-9, 40.

Abstract

The results showed that the concentration of unconjugated bilirubin (UCB) in the bile was higher than that in the normal controls (P less than 0.01), while the total bilirubin remained normal. The constituent ratio of bilirubin monoglucuronide and diglucuronide exhibited no marked difference between these two groups. The concentration of total bile acids (TBA) in cirrhotic rats was lower than that in the normals (P less than 0.001). In cirrhotic rats, some bile acids, e.g., TCA TCDCA GCA and GCDCA decreased while TLCA increased. Changes in the concentration of UCB and TBA correlated to the degree of fatty degeneration of the liver without cirrhosis, but this correlation disappeared once cirrhosis was formed. It is concluded that increased UCB and decreased TBA may be the factors responsible for the formation of pigment gallstones in cirrhotic patients.

摘要

结果显示，胆汁中未结合胆红素（UCB）的浓度高于正常对照组（P<0.01），而总胆红素仍保持正常。两组之间胆红素单葡萄糖醛酸酯和双葡萄糖醛酸酯的构成比无明显差异。肝硬化大鼠总胆汁酸（TBA）的浓度低于正常大鼠（P<0.001）。在肝硬化大鼠中，一些胆汁酸，如TCA、TCDCA、GCA和GCDCA减少，而TLCA增加。UCB和TBA浓度的变化与无肝硬化肝脏的脂肪变性程度相关，但一旦形成肝硬化，这种相关性就消失了。结论是，UCB升高和TBA降低可能是肝硬化患者色素性胆结石形成的原因。