感染与缺血性卒中的预后。
Infections and ischemic stroke outcome.
作者信息
Grabska Katarzyna, Gromadzka Grażyna, Członkowska Anna
机构信息
2nd Department of Neurology, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland.
出版信息
Neurol Res Int. 2011;2011:691348. doi: 10.1155/2011/691348. Epub 2011 Jun 28.
Background. Infections increase the risk of ischemic stroke (IS) and may worsen IS prognosis. Adverse effects of in-hospital infections on stroke outcome were also reported. We aimed to study the prevalence of pre- and poststroke infections and their impact on IS outcome. Methods. We analysed clinical data of 2066 IS patients to assess the effect of pre-stroke and post-stroke infections on IS severity, as well as short-term (up to 30 days) and long-term (90 days) outcome. The independent impact of infections on poor outcome (death, death/dependency) was investigated by use of logistic regression analysis. The effect of antibiotic therapy during hospitalization on the outcome was also assessed. Results. Pre-stroke infections independently predicted worse short-term outcome. In-hospital infections were associated with worse short-term and long-term IS prognosis. Antibacterial treatment during hospitalization did not improve patients' outcome. Conclusions. Prevention of infections may improve IS prognosis. The role of antibiotic therapy after IS requires further investigations.
背景。感染会增加缺血性中风（IS）的风险，并可能使IS的预后恶化。也有关于医院内感染对中风结局的不良影响的报道。我们旨在研究中风前后感染的患病率及其对IS结局的影响。方法。我们分析了2066例IS患者的临床数据，以评估中风前和中风后感染对IS严重程度以及短期（至30天）和长期（90天）结局的影响。通过逻辑回归分析研究感染对不良结局（死亡、死亡/依赖）的独立影响。还评估了住院期间抗生素治疗对结局的影响。结果。中风前感染独立预测短期结局较差。医院内感染与较差的短期和长期IS预后相关。住院期间的抗菌治疗并未改善患者的结局。结论。预防感染可能会改善IS的预后。IS后抗生素治疗的作用需要进一步研究。
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