季铵硅烷偶联剂的合成及其抗菌活性

Synthesis and antimicrobial activity of quaternary ammonium silane coupling agents.

作者信息

Yoshino Norio, Sugaya Shigenori, Nakamura Toshimitsu, Yamaguchi Yoh-hei, Kondo Yukishige, Kawada Kazuo, Teranaka Toshio

机构信息

Faculty of Engineering, Tokyo University of Science, Tokyo, Japan.

出版信息

J Oleo Sci. 2011;60(8):429-38. doi: 10.5650/jos.60.429.

DOI:10.5650/jos.60.429

PMID:21768744

Abstract

Fourteen novel silane coupling agents with a quaternary ammonium group introduced into the molecule, [CH(2)=CHCH(2)N(+)(CH(3))(C(n)H(2n+1))(CH(2))(3)Si(OCH(3))(3)]X(-) (n-X, n=10-18, X=Cl, Br, or I), were synthesized with the aim of using these agents to make material surfaces antimicrobial for a long period of time. Measurements of the minimum inhibitory concentrations (MIC) against 12 kinds of fungi and bacteria revealed that the coupling agent with a C(10) alkyl chain and Cl- or Br- counter-ion (10-Cl or 10-Br) has the highest antimicrobial activity among the n-X agents synthesized, but 14-Cl and 14-Br showed the highest activity on a modified porcelain plate.

摘要

合成了十四种分子中引入季铵基团的新型硅烷偶联剂，即[CH(2)=CHCH(2)N(+)(CH(3))(C(n)H(2n+1))(CH(2))(3)Si(OCH(3))(3)]X(-)（n-X，n = 10 - 18，X = Cl、Br或I），目的是利用这些偶联剂使材料表面具有长效抗菌性能。对12种真菌和细菌的最低抑菌浓度（MIC）测定表明，具有C(10)烷基链和Cl-或Br-抗衡离子的偶联剂（10-Cl或10-Br）在所合成的n-X偶联剂中具有最高的抗菌活性，但14-Cl和14-Br在改性瓷板上表现出最高活性。