Department of Radiology, Otto von Guericke University, Medical School, Magdeburg, Germany.
J Magn Reson Imaging. 2011 Oct;34(4):874-9. doi: 10.1002/jmri.22691. Epub 2011 Jul 18.
Image acquisition was performed using a 1T open-configured scanner suitable for interventional purposes. Transversal postcontrast T1-weighted (T1w) fat-saturated 3D high-resolution examination (THRIVE) images were acquired >20 minutes postintravenous application of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA). A single slice, crossing the level of the lesion, was acquired using intermediate-weighted steady-state free-precession (bTFE), T1w-gradient echo and spin echo (T1FFE/TSE), T2w-spin echo (sshTSE) sequences. T1w imaging was acquired prior and after contrast media application. Diagnostic and fast dynamic images were compared based on a 10-point rating scale. In addition, the liver-to-lesion-contrast ratio was measured.
A total of 39 malignant lesions with a mean diameter of 13 mm (5-30 mm) in 39 patients were included. Concerning a test of noninferiority, there was no significant difference between rating score values of fast dynamic imaging employing contrast-enhanced T1FFE-sequences compared to diagnostic THRIVE (P = 0.001). Calculated liver-to-lesion contrast also showed no difference for either imaging sequence (P = 1.0). All other sequences tested showed significant inferiority (P ≤ 0.001).
T1w Gd-EOB-DTPA contrast-enhanced fast dynamic GRE imaging significantly improves the contrast behavior of malignant liver lesions comparable to diagnostic imaging and is best suited for liver intervention, especially at 1T open magnetic resonance imaging.
1)分析和比较快速动态成像序列与活检可疑肝脏病变。2)评估与非增强快速动态扫描和诊断性肝脏成像相比,使用肝细胞特异性对比剂的额外用途。
使用适用于介入目的的 1T 开放式扫描仪进行图像采集。在静脉内应用钆乙氧基苯甲基二乙三胺五乙酸(Gd-EOB-DTPA)后>20 分钟采集横向对比增强 T1 加权(T1w)脂肪饱和 3D 高分辨率检查(THRIVE)图像。使用中等加权稳态自由进动(bTFE)、T1w 梯度回波和自旋回波(T1FFE/TSE)、T2w 自旋回波(sshTSE)序列采集穿过病变水平的单个切片。在应用对比剂前后采集 T1w 成像。根据 10 分评分量表比较诊断和快速动态图像。此外,还测量了肝与病变对比度。
共纳入 39 名患者的 39 个恶性病变,平均直径为 13 毫米(5-30 毫米)。关于非劣效性检验,增强 T1FFE 序列的快速动态成像评分值与诊断性 THRIVE 之间无显著差异(P=0.001)。计算出的肝与病变对比度在两种成像序列中也无差异(P=1.0)。测试的所有其他序列均显示出显著的劣势(P≤0.001)。
T1w Gd-EOB-DTPA 对比增强快速动态 GRE 成像可显著改善恶性肝脏病变的对比行为,与诊断性成像相当,特别适用于 1T 开放式磁共振成像的肝脏介入治疗。