Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, 250 College St., Toronto, Ontario, Canada M5T 1R8.
Schizophr Res. 2011 Oct;132(1):24-7. doi: 10.1016/j.schres.2011.06.026. Epub 2011 Jul 19.
Emerging evidence suggests that motivational deficits are a central component of negative symptoms in schizophrenia, and linked to functional impairment characterizing this illness. This study extends previous cross-sectional findings by examining the concurrent contributions of baseline motivational deficits, other negative symptoms, and other symptom domains on longitudinal functional outcomes in schizophrenia. Results of this longitudinal examination of 18 patients from our previous pilot study reveal that amotivation accounts for 74% and 72% of the variance in functional outcomes at baseline and 6-month follow-up, respectively. These findings further suggest a fundamental role for motivational deficits in predicting functional outcomes in schizophrenia.
新出现的证据表明，动机缺陷是精神分裂症阴性症状的一个核心组成部分，并且与该疾病的特征性功能障碍有关。这项研究通过检查基线动机缺陷、其他阴性症状和其他症状领域对精神分裂症纵向功能结果的同期贡献，扩展了以前的横断面研究结果。我们之前的试点研究中对 18 名患者进行的纵向研究结果表明，动机缺乏分别解释了基线和 6 个月随访时功能结果的 74%和 72%的变异。这些发现进一步表明，动机缺陷在预测精神分裂症的功能结果方面起着根本性的作用。
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