新型3-苯基-1-[(4-芳基哌嗪-1-基)烷基]-哌啶-2,6-二酮的合成与生物学评价
Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones.
作者信息
Bielenica Anna, Kossakowski Jerzy, Struga Marta, Dybała Izabela, Loddo Roberta, Ibba Cristina, La Colla Paolo
机构信息
Department of Medical Chemistry, First Faculty of Medicine, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland.
出版信息
Sci Pharm. 2011 Apr-Jun;79(2):225-38. doi: 10.3797/scipharm.1012-17. Epub 2011 Feb 12.
A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.
合成了一组13种3-苯基哌啶-2,6-二酮的烷基衍生物。对新得到的化合物进行了抗HIV-1和其他选定病毒的体外研究。苄基3f和氟苯基3g衍生物对CVB-2表现出中等程度的保护作用，化合物3g对HSV-1也有保护作用。还测试了这些衍生物的抗菌和抗真菌活性。通过X射线分析确定了3a和3d的分子结构。
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