帕金森病中的β-肾上腺素能敏感性：左旋多巴治疗的效果。
Beta-adrenergic sensitivity in Parkinson's disease: effect of levodopa treatment.
作者信息
Durrieu G, Rispail Y, Chatelut E, Berlan M, Rascol A, Montastruc J L, Montastruc P
机构信息
Laboratoire de Pharmacologie Médicale et Clinique, INSERM U317, Faculté de Médecine, Toulouse, France.
出版信息
Clin Neuropharmacol. 1990 Dec;13(6):492-9. doi: 10.1097/00002826-199012000-00002.
The beta-adrenergic sensitivity in never-treated and levodopa-treated patients with Parkinson's disease (PD) was studied through the evaluation of lymphocyte beta-adrenoceptor number ([125I]cyanopindolol binding sites) and chronotropic and metabolic (plasma nonesterified fatty acids--NEFA) responses to isoproterenol. No change was found in Bmax values or affinity constant Kd between never-treated patients, levodopa-treated patients with PD, and controls. At rest, no difference was observed in heart rate, plasma catecholamine, or NEFA levels between the three groups. Isoproterenol sensitivity (chronotropic response and plasma NEFA increase) was similar in never-treated and treated PD. The results suggest that peripheral beta-adrenergic sensitivity is unaffected either by the pathophysiological process of PD or by levodopa treatment.
通过评估淋巴细胞β-肾上腺素能受体数量（[125I]氰吲哚洛尔结合位点）以及对异丙肾上腺素的变时性和代谢性（血浆非酯化脂肪酸-NEFA）反应，研究了未经治疗和接受左旋多巴治疗的帕金森病（PD）患者的β-肾上腺素能敏感性。未经治疗的患者、接受左旋多巴治疗的PD患者和对照组之间，Bmax值或亲和常数Kd均未发现变化。静息时，三组之间的心率、血浆儿茶酚胺或NEFA水平均未观察到差异。未经治疗和接受治疗的PD患者对异丙肾上腺素的敏感性（变时性反应和血浆NEFA升高）相似。结果表明，外周β-肾上腺素能敏感性不受PD病理生理过程或左旋多巴治疗的影响。
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