甲状腺激素介导胰岛素对四氧嘧啶糖尿病大鼠心房的作用。

Thyroid hormones mediated effect of insulin on alloxan diabetic rat atria.

Karasu C, Oztürk Y, Altan N, Yildizoğlu-Ari N, Ikizler C, Altan V M

University of Ankara, Faculty of Pharmacy, Department of Pharmacology, Turkey.

Gen Pharmacol. 1990;21(5):735-40. doi: 10.1016/0306-3623(90)91026-n.

Abstract

The influence of alloxan-induced diabetes was studied on spontaneously beating rat atria. Diabetic atria were found to have decreased rates, increased contractility and decreased responsiveness to both inotropic and chronotropic effects of isoprenaline. 2. Thyroid hormone levels were significantly reduced in diabetic animals. This revealed that the decrease in atrial beta-adrenergic responses was associated with a reduction in serum levels of thyroid hormones. 3. Insulin treatment of diabetic rats for 10 days corrected the changes observed in diabetic atria. Serum levels of thyroid hormones returned to normal following insulin treatment as well. 4. Administration of insulin to thyroidectomized-diabetic rats did not reverse the diabetes-induced changes suggesting that thyroid hormones are needed for insulin to normalize the alterations observed in diabetic atria.

摘要

研究了四氧嘧啶诱导的糖尿病对大鼠自发性搏动心房的影响。发现糖尿病心房的心率降低、收缩性增加，对异丙肾上腺素的变力性和变时性作用的反应性降低。2. 糖尿病动物的甲状腺激素水平显著降低。这表明心房β-肾上腺素能反应的降低与血清甲状腺激素水平的降低有关。3. 对糖尿病大鼠进行10天的胰岛素治疗可纠正糖尿病心房中观察到的变化。胰岛素治疗后血清甲状腺激素水平也恢复正常。4. 对甲状腺切除的糖尿病大鼠给予胰岛素并不能逆转糖尿病引起的变化，这表明甲状腺激素是胰岛素使糖尿病心房中观察到的改变正常化所必需的。