State Key Laboratory of Oncology in South China and Department of Medical Imaging and Interventional Radiology, Cancer Center, SunYat-Sen University, Guangzhou, Guangdong, PR China.
J Otolaryngol Head Neck Surg. 2011 Aug;40(4):300-10.
To evaluate bony changes in the skull base after radiotherapy by computed tomography (CT) and their correlation with local recurrence in patients with nasopharyngeal carcinoma (NPC) without previous involvement of the skull base.
Retrospective study.
Sun-Yat Sen University Cancer Center.
The records of 80 patients with NPC during the period from January 1992 to December 2005 were reviewed. All patients had been treated with radical radiotherapy or chemoradiotherapy at standard doses and were followed up with plain and contrast-enhanced CT every 6 months for 45.5 (range 12-108) months.
The types, areas, time of the first occurrence after radiotherapy and development of the postradiation bony changes of the skull base, and local recurrence rates of NPC were measured.
Eighteen patients (22.5%) had sclerosis in some area of the skull base, and the sclerosis in 5 (27.8%) of these patients changed into osteoporosis in 1 to 5 years after its appearance. Seventeen patients (21.3%) had osteolysis. The local recurrence rate of patients with osteolysis was observed to be significantly higher than that of patients with sclerosis (p < .0001).
The appearance of osteolytic changes in the skull base during follow-up of patients with NPC who had normal skull base morphology before treatment was associated with tumour recurrence.
通过计算机断层扫描(CT)评估鼻咽癌(NPC)患者放疗后颅底的骨质变化及其与无颅底先前受累患者局部复发的相关性。
回顾性研究。
中山大学肿瘤防治中心。
回顾了 1992 年 1 月至 2005 年 12 月期间 80 例 NPC 患者的记录。所有患者均接受根治性放疗或标准剂量的放化疗,随访时间为 45.5(12-108)个月,每 6 个月进行一次平扫和增强 CT。
测量放疗后颅底骨质变化的类型、部位、首次出现时间以及 NPC 局部复发率。
18 例(22.5%)患者颅底某一部位出现硬化,其中 5 例(27.8%)患者在出现硬化后 1-5 年内转变为骨质疏松。17 例(21.3%)患者出现骨质溶解。骨质溶解患者的局部复发率明显高于骨质硬化患者(p <.0001)。
治疗前颅底形态正常的 NPC 患者在随访期间出现颅底溶骨性变化与肿瘤复发有关。