Bell Christopher G
Medical Genomics, UCL Cancer Institute, University College London, London, UK.
Methods Mol Biol. 2011;760:1-17. doi: 10.1007/978-1-61779-176-5_1.
The history of genetic markers accurately partitions the progression of molecular genetics into three phases: the RFLP (restriction fragment length polymorphism), microsatellite and SNP (single nucleotide polymorphism) eras. This chapter focuses predominately on the current workhorse, the SNP, though briefly covers the former two and overviews current online databases and portals that act as central repositories as well as hubs to further detailed information. Central gene or disease-based searches are considered and then followed through systematically.
限制性片段长度多态性(RFLP)、微卫星和单核苷酸多态性(SNP)时代。本章主要聚焦于当前的主力军——SNP,不过也简要介绍了前两者,并概述了当前作为中央存储库以及获取更详细信息的枢纽的在线数据库和门户网站。文中考虑了基于核心基因或疾病的搜索,然后进行系统的跟进。