Division of Urology, Department of Surgery, Cardinal Tien Hospital, and Graduate Institute of Basic Medicine, Fu Jen Catholic University College of Medicine, Taipei, Taiwan.
Urology. 2011 Sep;78(3):631-5. doi: 10.1016/j.urology.2011.05.033. Epub 2011 Jul 22.
To investigate the association between serum sex hormone levels and lower urinary tract symptoms in men aged 40-79 years.
A cross-sectional study was conducted in 509 men (mean age 58 years). The serum total testosterone (TT), dihydrotestosterone, and estradiol levels were measured. The total prostate volume measured by transrectal ultrasonography and International Prostate Symptom Score (IPSS) questionnaire were obtained. Correlations were determined using univariate and multivariate regression analysis.
The subjects with moderate to severe lower urinary tract symptoms (total IPSS≥8) were older, with a greater incidence of hypertension and diabetes, a larger prostate, and had lower serum TT levels. On the univariate analysis, the serum TT levels were negatively associated with the total IPSS, IPSS storage subscore, weak stream, and nocturia. After adjusting for age, hypertension, diabetes, and total prostate volume, only the serum TT level was significantly associated with nocturia (>2 times/night; P=.042), and men with serum TT levels in the greatest quartile had a 44% reduced risk of nocturia than in the lowest quartile (P=.037).
In our relative healthy male cohort, most IPSS items showed no significant association with serum sex hormone levels, except for nocturia, which showed a negative correlation with the serum testosterone level.
探讨 40-79 岁男性血清性激素水平与下尿路症状之间的关系。
本研究为横断面研究，共纳入 509 名男性（平均年龄 58 岁）。检测血清总睾酮（TT）、二氢睾酮和雌二醇水平，经直肠超声测量前列腺总体积，采用国际前列腺症状评分（IPSS）问卷评估下尿路症状。采用单因素和多因素回归分析确定相关性。
中重度下尿路症状（总 IPSS≥8）患者年龄较大，高血压和糖尿病发病率较高，前列腺较大，血清 TT 水平较低。单因素分析显示，血清 TT 水平与总 IPSS、IPSS 储尿症状评分、尿流弱和夜尿均呈负相关。校正年龄、高血压、糖尿病和前列腺总体积后，仅血清 TT 水平与夜尿（>2 次/夜；P=.042）显著相关，血清 TT 水平最高四分位组的夜尿发生风险较最低四分位组降低 44%（P=.037）。
在我们相对健康的男性队列中，大多数 IPSS 项目与血清性激素水平无显著相关性，除夜尿外，其与血清睾酮水平呈负相关。
