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儿童期星形细胞瘤放疗后引起的烟雾病。

Radiation-induced moyamoya disease after childhood astrocytoma.

机构信息

Department of Neurosurgery, 7th Floor, Gold Coast Hospital, 108 Nerang Street, Southport, Queensland 4215, Australia.

出版信息

J Clin Neurosci. 2011 Oct;18(10):1403-5. doi: 10.1016/j.jocn.2011.01.032. Epub 2011 Jul 23.

Abstract

Adjunctive radiation treatment of childhood intracranial neoplasms of grade II or higher creates a risk of subsequent vasculopathy. A 28-year-old male presented with a Glasgow Coma Scale 12 after acute collapse and hemiparesis with an intraparenchymal haematoma. Emergent craniotomy, histopathology and subsequent imaging confirmed the cause as radiation-induced moyamoya disease, subsequent to treatment for a grade 2 astrocytoma 24 years previously. He had been lost to follow-up after normal serial imaging performed up to 10 years after his initial diagnosis. Long term surveillance imaging may be of benefit in identifying treatable vascular anomalies.

摘要

儿童颅内 II 级或以上肿瘤的辅助放射治疗会增加血管病变的风险。一名 28 岁男性因突发性头痛、偏瘫和脑实质血肿导致格拉斯哥昏迷评分 12 分。紧急开颅手术、组织病理学和随后的影像学检查证实病因是放射诱导的烟雾病,此前 24 年前曾因二级星形细胞瘤接受治疗。他在最初诊断后 10 年内进行了正常的连续影像学检查,之后就失去了随访。长期监测影像学检查可能有助于发现可治疗的血管异常。

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